منابع مشابه
Small GTPases.
Members of the protein superfamily of small guanosine triphosphatases, also known as small GTPases, small G-proteins, or the Ras superfamily, are involved in nearly every aspect of cell biology. Small GTPases are tightly regulated molecular switches that make binary on/off decisions through controlled loading of GTP (activation) and hydrolysis of GTP to GDP (inactivation). Small GTPases typical...
متن کاملSmall GTPases minireview series.
Small GTPases are monomeric guanine nucleotide-binding proteins of 20–25 kDa molecular mass. They play major roles in the regulation of growth, morphogenesis, cell motility, axonal guidance, cytokinesis, and trafficking through the Golgi, nucleus, and endosomes. The first small GTPase to be discovered was Ras, and there are now many members of the Ras superfamily of GTPases. These are grouped i...
متن کاملIn this issue of Small GTPases
One way to study the molecular mechanisms that the Arf family of GTPases uses to regulate intracellular traffic and organelle structure requires in vitro biochemical assays. However, it is important to use a recombinant Arf protein that is in its cellular, myristoylated form, a form that is difficult to purify. In this research paper, Padovani et al. have found an efficient way to produce highl...
متن کاملRole of small GTPases in endothelial cytoskeletal dynamics and the shear stress response.
Fluid shear stress caused by blood flow is a major determinant of vascular remodeling and arterial tone and can lead to development of atherosclerosis. The endothelial monolayer in vivo acts as a signal transduction interface for hemodynamic forces; these forces determine the shape, cytoskeletal organization, and function of endothelial cells, allowing the vessels to cope with physiological or ...
متن کاملCell adhesion and Rho small GTPases.
The Rho small GTPases, Cdc42, Rac1 and Rho, are implicated in regulation of integrin-mediated cell-substratum adhesion and cadherin-mediated cell-cell adhesion. Identification and characterization of effectors of these GTPases have provided insights into their modes of action. Rho-kinase, an effector of Rho, regulates integrin-mediated cell-substratum adhesion (focal adhesion) by regulating the...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2016
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2016.01.004